War Machine: Tony Stark allows one Iron Man armor to be used by the U.S. military under the auspices of his close friend, Air Force officer Lieutenant Colonel James Rhodes. Heavily armed with Hammer Industries weaponry, "Rhodey" is the armor's sole pilot.

Maya Hansen: An old colleague and romantic interest of Tony Stark's, Maya Hansen was more interested in the biological side of science than the technological, and she ultimately developed the Extremis formula that could turn a human into a living weapon.