Punisher: Dispensing his own brand of vigilante justice, Frank Castle is often at odds with costumed heroes, and even tried to eliminate Spider-Man in the early days of his career. Most of them steer clear of this ex-soldier for their own safety.

Deadpool: To cure his terminal lung cancer, mercenary Wade Wilson attempted to obtain mutant powers through artificial means. However, the side effects of the procedure disfigured him and also caused extensive psychological damage.