Peter Parker: When Captain Stacy of the NYPD was killed while fighting the Lizard, Peter swore to him he would stay away from Stacy's daughter, in order to keep her safe. But Peter finds himself unable (or unwilling) to keep his distance.

Gwen Stacy: A brilliant fellow student at Peter's high school, Gwen is one of the few who knows his secret identity as Spider-Man. her part-time job at OsCorp is often a help to Peter, but it also puts her in danger.