Anti-Sinister Six Spider-Man: Spider-Man's greatest foes have a habit of teaming up against him. After his last tangle with the Sinisther Six, Peter Parker developed a new suit of armor he could use against them.

Mysterio: The illusionist and criminal Quentin Beck has faked his death numerous times, but he has always resurfaced to menace Spider-Man, either on his own or as a member of the Sinister Six.