Wolverine: James Howlett's healing factor, retractable claws and enhanced senses made him the perfect candidate for the Weapon Plus program but Wolverine's decision to join the X-Men is what made him a hero.
Deadpool: Known as the "Merc with a Mouth," Wade Wilson was transformed into the antihero Deadpool after the Weapon X program treated his terminal cancer with DNA extracted from Wolverine. He now enjoys cracking jokes, getting paid and Bea Arthur.