First Appearance Deadpool: Wade Wilson began his mercenary career while still in his late teens. Wilson became a test subject in Department K's branch of the joint U.S./Canadian superhuman enhancement project, the Weapon X Program. Deadpool would later meet defeat at the hands of Cable and his new charges, the young mutants in training known as the New Mutants.

X-Force Cable: Nathan Summers' birth was carefully orchestrated by the geneticist Mister Sinister. Sinister planned to use Nate as a weapon against his former master Apocalypse, but Apocalypse learned of this and had Nate captured and infected with a deadly techno-organic virus. Later, with the aid of his mercenary ally and sometime lover Domino, Cable reorganized the New Mutants into the strike team X-Force.

Domino: Neena Thurman was one of the many children born to the U.S. government's Project: Armageddon, designed to genetically engineer the perfect weapon using a precognitive mutant named Beatrice. Domino was once captured by the arms dealer Tolliver, secretly Cable's estranged son Tyler, who had one of his agents impersonate Domino in Caple's new strike-team X-Force. Cable ultimately freed her and she came to aid him in his role as X-Force's leader.

Feral: Maria Callasantos and her three siblings, Lucia, Matteo, and Carolina, grew up poor and abandoned by their father. After Maria's mutant powers emerged she found refuge with the underground Morlocks. She later agreed to join the New Mutants in return for their help in taking down Masque, and the team soon after became X-Force.