Dormammu: Master of the Dark Dimension, the Dread Dormammu has crossed over to the real world in hopes of conquering it. Among his many abilities are matter transmutation, interdimensional teleportation, size and shape alteration, element control and telepathy.

Trish: Originally created by a demon in order to lure Dante into a trap, Trish worked side-by-side with him and fell victim to his charms, ultimately betraying the demon world. Now she works together with Dante as his business partner, and wields lightning based powers.