Spider-Man: While attending a science exhibit, young Peter Parker was bitten by a radioactive spider, gaining its strength and wall-crawiling ablities. At first he sought fame as an entertainer, but when his uncle was killed by a criminal he had let escape, Peter learned that "with great power comes great responsibility."

Green Goblin: Scientist Norman Osborne was developing a formula that would enhance strength and intelligence, but when he exposed himself to the untested serum, he discovered its terrible side effect: madness! Super-strong and super-smart, the criminal mastermind called the Green Goblin is also super-dangerous.